It’s Not Oral.
It’s Not IV.

It’s Enbumyst.

What is Enbumyst?

Enbumyst is a prescription medicine used in adults to treat swelling caused by too much fluid in the body (edema) from congestive heart failure, liver disease and kidney disease, including a kidney problem called nephrotic syndrome.

Who should not use Enbumyst?

Do not use Enbumyst if you have very low or no urine production or are allergic to bumetanide or to any of the ingredients in Enbumyst. See the Patient Information for a complete list of ingredients in Enbumyst.

Please see Important Safety Information below.

Why Enbumyst?

  • Demonstrated similar effects on diuresis, natriuresis, and urinary potassium excretion as oral bumetanide tablets and IV injection¹
  • Single-use nasal spray that is designed for ease of use in any setting
  • Intranasal route avoids reliance on GI absorption
  • Same device platform found in certain FDA-approved emergency intranasal therapies
  • Intended to support outpatient stabilization and care continuity
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Watch: How to Use Enbumyst

Indication & Important Safety Information

WHAT IS ENBUMYST?

Enbumyst is a prescription medicine used in adults to treat swelling caused by too much fluid in the body (edema) from congestive heart failure, liver disease and kidney disease, including a kidney problem called nephrotic syndrome.

IMPORTANT SAFETY INFORMATION
What is the most important information that I should know about Enbumyst?

Enbumyst is a diuretic that causes fluid loss and may lead to abnormalities with blood electrolytes and body energy systems (metabolic). Too much fluid loss can lead to dehydration and low blood volume, which may increase your risk of blood clots. Blood abnormalities may include decreased salts (electrolytes), and increased nitrogen, glucose and uric acid. The chance of getting these abnormalities is higher in people who are elderly, use higher doses, or who do not get enough electrolytes by mouth. Your healthcare provider should do blood tests to check for these abnormalities during treatment with Enbumyst. You should not use Enbumyst if you have severe electrolyte loss until it gets better.

Who should not use Enbumyst?

Do not use Enbumyst if you have very low or no urine production or are allergic to bumetanide or to any of the ingredients in Enbumyst. See the Patient Information for a complete list of ingredients in Enbumyst.

What are the side effects of Enbumyst?

ENBUMYST may cause serious side effects, including:

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See “What is the most important information I should know about ENBUMYST?”
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Worsening kidney function. Your healthcare provider may stop treatment if your kidney function gets worse.
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Ear damage (ototoxicity) including ringing in the ears (tinnitus) or hearing loss, especially in people with severe kidney problems, taking higher than recommended doses, with low levels of protein in the blood, and when used with certain other medicines.

Common side effects of Enbumyst include: low levels of fluid in the body, headache, muscle cramps, dizziness, low blood pressure, nausea, and abnormal brain functioning in people with certain liver problems.

Tell your healthcare provider if you have any side effects that bother you or that do not go away after using Enbumyst.

These are not all of the possible side effects of Enbumyst. Call your healthcare provider for medical advice about side effects. To report side effects, contact Corstasis Therapeutics Inc. at 1-877-300-5339 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see the full Prescribing Information and Patient Information for Enbumyst.

References:
1. Enbumyst Prescribing Information. Corstasis Therapeutics Inc. 11/2025